Target removes gender based signage for kids

[oncemoreuntothejimbreech]

(08-25-2015, 07:46 PM)Mike M (the other one) Wrote: However, that is not why they ended up obese or an alcoholic. Environmental factors/social factors played a much bigger role is them getting it.

This is what many of you keep ignoring about this whole genetic argument.

Genetic predisposition can contribute to the development of a disease, but it will not directly cause it. Some with a certain predisposing genetic variation will never get it, while others can, even inside of the same family/genetic line.



The test is a false one from the start. You will be able to find certain markers/mutations that could contribute to it and increase the probability of someone getting a disease but:

Genetic predisposition can contribute to the development of a disease, but it will not directly cause it.

Let's not go to far off topic, but just an interesting tidbit about eye color:
A person's eye colors can change. For example, during pregnancy the pigmentation in the eyes gets darker. 15% of people report that it changes after puberty. Other things such as the food you eat, or stress can also alter your eye color. Age can also change the color of your eyes.

Genetics is nothing more than a recipe book. It gives you the recipe to create the proteins that make up the pigmentation in the eyes, and like a cook who uses the same recipe over and over again, sometimes the results might not always the same. IE Flame on oven hotter/colder, ingredients not as pure as previous time(s) etc.

But again, all of those instances are environmental factors, and not due to some hereditary genetic gene(s).

I think you get the picture, so I won't go further.

First things first.  When it comes to science and medicine, I have yet to see you post anything which is even remotely correct.  Even when you plagiarize, you are somehow able to misrepresent the facts.

Here's the website you plagiarized . . .  http://ghr.nlm.nih.gov/handbook/mutationsanddisorders?show=all

 Here is something you didn't include.  I'll post the entire section rather than a single sentence taken out of context to misrepresent the truth.

Quote:How can gene mutations affect health and development?

To function correctly, each cell depends on thousands of proteins to do their jobs in the right places at the right times. Sometimes, gene mutations prevent one or more of these proteins from working properly. By changing a gene’s instructions for making a protein, a mutation can cause the protein to malfunction or to be missing entirely. When a mutation alters a protein that plays a critical role in the body, it can disrupt normal development or cause a medical condition. A condition caused by mutations in one or more genes is called a genetic disorder.

In some cases, gene mutations are so severe that they prevent an embryo from surviving until birth. These changes occur in genes that are essential for development, and often disrupt the development of an embryo in its earliest stages. Because these mutations have very serious effects, they are incompatible with life.

It is important to note that genes themselves do not cause disease—genetic disorders are caused by mutations that make a gene function improperly. For example, when people say that someone has “the cystic fibrosis gene,” they are usually referring to a mutated version of the CFTR gene, which causes the disease. All people, including those without cystic fibrosis, have a version of the CFTR gene.

For more information about mutations and genetic disorders:

The Centre for Genetics Education offers a fact sheet about genetic changes that lead to disorders.
The Tech Museum of Innovation offers a brief overview of genetic mutations and disease.

Everybody has genes.  Genes don't cause disease.  Mutated genes cause disease.  The mutated genes causes abnormal function which causes the disease.  People who are genetically predisposed to genetic diseases have a known family history of an inherited disease occurring over multiple generations of their family.

Quote:What does it mean to have a genetic predisposition to a disease?

A genetic predisposition (sometimes also called genetic susceptibility) is an increased likelihood of developing a particular disease based on a person’s genetic makeup. A genetic predisposition results from specific genetic variations that are often inherited from a parent. These genetic changes contribute to the development of a disease but do not directly cause it. Some people with a predisposing genetic variation will never get the disease while others will, even within the same family.

Genetic variations can have large or small effects on the likelihood of developing a particular disease. For example, certain mutations in the BRCA1 or BRCA2 genes greatly increase a person’s risk of developing breast cancer and ovarian cancer. Variations in other genes, such as BARD1 and BRIP1, also increase breast cancer risk, but the contribution of these genetic changes to a person’s overall risk appears to be much smaller.

Current research is focused on identifying genetic changes that have a small effect on disease risk but are common in the general population. Although each of these variations only slightly increases a person’s risk, having changes in several different genes may combine to increase disease risk significantly. Changes in many genes, each with a small effect, may underlie susceptibility to many common diseases, including cancer, obesity, diabetes, heart disease, and mental illness.

In people with a genetic predisposition, the risk of disease can depend on multiple factors in addition to an identified genetic change. These include other genetic factors (sometimes called modifiers) as well as lifestyle and environmental factors. Diseases that are caused by a combination of factors are described as multifactorial. Although a person’s genetic makeup cannot be altered, some lifestyle and environmental modifications (such as having more frequent disease screenings and maintaining a healthy weight) may be able to reduce disease risk in people with a genetic predisposition.

For more information about genetic predisposition to disease:

The World Health Organization offers information about genetic predisposition to several common diseases, including cancer, diabetes, cardiovascular disease, and asthma.

Genetic Alliance UK offers a fact sheet on genetic predisposition to common genetic diseases.
The Genetic Science Learning Center at the University of Utah provides more information about calculating the risk of genetic diseases and predicting disease based on family history.

The Coriell Personalized Medicine Collaborative explains genetic and nongenetic risk factors for complex diseases.
More detailed information about the genetics of breast and ovarian cancer is available from the National Cancer Institute.

Genetic predisposition means you have an increased chance of inheriting mutated genes which cause disease.  Take cystic fibrosis for example.  If you have a parent with cystic fibrosis you are more likely to get cystic fibrosis by inheriting the mutated gene which causes cystic fibrosis.  The cystic fibrosis gene is autosomal recessive which means you must get a copy from each parent.  That is why some of their children may not get cystic fibrosis.  But, if a child has cystic fibrosis it is a 100% certainty each parent is a carrier of a mutated CF gene