Would you use a 1st Round pick on someone you knew we wouldn't keep?

[THE PISTONS]

I see people who want a Guard in the 1st Round, and it's basically a given that if the Guard develops that we won't pay top dollar to keep him/or her.

There are however other positions that we do have a history of paying a premium for and keeping (WR, Tackle, QB, DT, DE, CB).

What would your strategy be?