05-20-2020, 08:18 AM
In case anyone is curious about hydrochloroquine and how things are going: https://clinicaltrials.gov/ct2/show/study/NCT04370782
I have a tendency to favor data and science, which apparently means I just dislike things Trump says and does because it's Trump, so this is an interesting thing to keep an eye on for the clinical trials of the treatment.
I'm also fairly certain this will be locked down for anyone lacking a subscription to the journal, but here it is: https://www.sciencedirect.com/science/article/pii/S0883944120303907
"A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19"
I have a tendency to favor data and science, which apparently means I just dislike things Trump says and does because it's Trump, so this is an interesting thing to keep an eye on for the clinical trials of the treatment.
I'm also fairly certain this will be locked down for anyone lacking a subscription to the journal, but here it is: https://www.sciencedirect.com/science/article/pii/S0883944120303907
"A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19"
Quote:Abstract
Purpose
COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19.
Methods
PubMed, EMBASE, and three trial Registries were searched for studies on the use of chloroquine in patients with COVID-19.
Results
We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. Chloroquine seems to be effective in limiting the replication of SARS-CoV-2 (virus causing COVID-19) in vitro.
Conclusions
There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. Safety data and data from high-quality clinical trials are urgently needed.
"A great democracy has got to be progressive, or it will soon cease to be either great or a democracy..." - TR
"The test of our progress is not whether we add more to the abundance of those who have much; it is whether we provide enough for those who have too little." - FDR
"The test of our progress is not whether we add more to the abundance of those who have much; it is whether we provide enough for those who have too little." - FDR